Rahsaan:
In some cases, most certainly. But I was speaking to the trope, the "rule" that you're not supposed to consume spirits before wine because, supposedly spirits dull or obliterate the sensitive little taste buds.
There are people who maintain that the poor wines---or the poor taste buds---just can't handle it. Which is bullshit.
But by using a modicum of sense---one would not, hopefully, gulp down a couple of sticky creme de menthe Grasshopper drinks just before opening a Romanee-Conti---conflicts can be avoided.
In Portland, the mass of disgusting sweet and sticky drinks are in the minority (at least at the places I drink), and the bartenders here are clearly in the "bitters" zone, and are looking for interesting and compellling----and taste-driven---cocktails. These types of cocktails are actually designed for the taste buds, and so are in keeping with the idea of consuming one prior toa meal rather than strictly alone, or after a meal.
One of the themes that is popular right now, as a matter of fact, is the 'culinary cocktail', where fruits and vegetables (and even things like bacon, yes) are used in cocktails. There's one at a local hip bar that uses as an ingredient duck fat (as a wash). I haven't had that drink.
It is common now to see drinks, especially aperitifs, that use Sanbitter, Aperol, Chartreuse, Cynar, Cocchi Americano, and the better vermouths. Common in Europe (where it is also common to use cocktails like this as an aperitif), but only now becoming common here.
So, yes, cocktails/mixed drinks can most certainly abuse the palate. But then, consuming certain wines can abuse the palate equally as much, not so? And one does have to assume a moderate amount of intelligence in the consumption of anything. Dangerous with many people, that; but there it is.
