by Max Hauser » Fri Oct 19, 2007 4:13 am
Hi Mark. From your reply, maybe my one-liner gave the impression of claiming synthetic medications were only significant in the last couple generations, which wasn't my intent. See what you think of this elaboration.
In human-history terms, the era of synthetic pharmacy is very recent. It's not just that the recorded Western pharmacopoeia between roughly Galen and penicillin came mainly from natural sources (some would fault me for not starting with the Papyrus Ebers, 1700 years before Galen, but Galen overshadowed it). Most natural medications were herbal (there were important animal sources, and in the last few hundred years powerful inorganic agents -- mercury, ferro-arsene, etc. -- came into, then went out of, medical use). What is more striking is how far into the 20th century a sophisticated herbal technology remained important. I wrote above that most medicines had herbal origins (vs. the synthetics later dominant) because that's the picture conveyed by the mainstream medical and pharmaceutical texts I have from 1900-1950. Without them I would never have appreciated this. US pharmacists training even in the middle 1950s (one of them is a wine-tasting friend, and even used as texts some of the same titles I have) had to become skilled botanical chemists: semesters of "pharmacognition" courses on recognizing plants, knowing which parts were active, and extracting the principles. Pharmacists were required (again, until relatively recently) to know how to make their medicines from "scratch." The mid-century Merck Index, my source above on gentian etc., contrasts radically and fascinatingly from modern editions in its emphasis on plant biochemicals. Synthetics began appearing, of course, as you mentioned (I could give you more of that history if you like) but they didn't displace the existing pharmacopoeia overnight. Even in sources like Burack's 1969 prescription-drugs book and the contemporaneous eds. of Goodman and Gilman, it's striking how many common meds even in the late 1960s were recognizably herbal in origin -- no longer a majority, but still significant.
That's the background. My point in raising it was that in the time humans have consumed bitters and other herbal cordials, these were linked with medicines more often than not. In fact there's much more: popular drinks from absinthe to Coca-Cola (tm) started out as medicines, and others once popular have faded out, often for good reasons (like Mariani wine, containing a generous dose of cocaine).